PGC-1 mediates exercise-induced skeletal muscle VEGF expression in mice
نویسندگان
چکیده
Lotte Leick, Ylva Hellsten, Joachim Fentz, Stine S. Lyngby, Jørgen F. P. Wojtaszewski, Juan Hidalgo, and Henriette Pilegaard Centre of Inflammation and Metabolism and Copenhagen Muscle Research Centre, Department of Biology, Section of Molecular, Cellular, and Integrative Physiology; Copenhagen Muscle Research Centre, Molecular Physiology Group, Section of Human Physiology, Department of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark; and Institute of Neurosciences and Department of Cellular Biology, Physiology, and Immunology, Autonomous University of Barcelona, Barcelona, Spain
منابع مشابه
The transcriptional coactivator PGC-1alpha mediates exercise-induced angiogenesis in skeletal muscle.
Peripheral arterial disease (PAD) affects 5 million people in the US and is the primary cause of limb amputations. Exercise remains the single best intervention for PAD, in part thought to be mediated by increases in capillary density. How exercise triggers angiogenesis is not known. PPARgamma coactivator (PGC)-1alpha is a potent transcriptional co-activator that regulates oxidative metabolism ...
متن کاملPGC-1alpha plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle.
Endurance exercise stimulates peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) expression in skeletal muscle, and forced expression of PGC-1alpha changes muscle metabolism and exercise capacity in mice. However, it is unclear if PGC-1alpha is indispensible for endurance exercise-induced metabolic and contractile adaptations in skeletal muscle. In this study, we s...
متن کاملPGC-1 isoforms and their target genes are expressed differently in human skeletal muscle following resistance and endurance exercise
The primary aim of the present study was to investigate the acute gene expression responses of PGC-1 isoforms and PGC-1α target genes related to mitochondrial biogenesis (cytochrome C), angiogenesis (VEGF-A), and muscle hypertrophy (myostatin), after a resistance or endurance exercise bout. In addition, the study aimed to elucidate whether the expression changes of studied transcripts were link...
متن کاملSkeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression
Depression is a debilitating condition with a profound impact on quality of life for millions of people worldwide. Physical exercise is used as a treatment strategy for many patients, but the mechanisms that underlie its beneficial effects remain unknown. Here, we describe a mechanism by which skeletal muscle PGC-1α1 induced by exercise training changes kynurenine metabolism and protects from s...
متن کاملSimultaneous Effect of Resistance Training and Endothelial Progenitor Cell Injection on the Expression of Vegf Angiogenic Factor and Its Relationship with Insulin Resistance in Diabetic Male Rats Induced By Stz
Background: Exercise and the simultaneous use of progenitor cells is a new strategy aimed for reducing diabetic disorders. One of the known mechanisms is angiogenic disorders caused by diabetes. Therefore, the present study was performed to determine the simultaneous effect of resistance training with endothelial progenitor cell injection on the expression of angiogenic factors in the skeletal ...
متن کامل